In recent years, the landscape of cannabis accessibility has dramatically shifted, not just in conventional dispensaries but in everyday storefronts across the United States. This new wave of products, stemming from the 2018 Farm Bill's legal distinction between hemp and marijuana, has ushered in an era of synthetic cannabinoids like Delta-8 THC, Delta-10 THC, and THCA, which are finding their way into the hands of consumers and, inevitably, into emergency departments. As emergency clinicians, it's crucial to understand the implications of these substances, their legal ambiguities, and their effects on public health.